The following studies are only an excerpt of wIRA publications, please contact us for more detailed information.


Thomsen AR,  Saalmann MR, Nicolay NH, Grosu AL, Vaupel P.
Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers Upon Mild Hyperthermia Delivered by WIRA-Irradiation. Adv Exp Med Biol. 2022;1395:255-261. (DOI: 10.1007/978-3-031-14190-4_42)


Guevara Solarte DL, Rau SJ, Hellwig E, Vach K, Al-Ahmad A.
Antimicrobial Behavior and Cytotoxicity of Indocyanine Green in Combination with Visible Light and Water-Filtered Infrared A Radiation against Periodontal Bacteria and Subgingival Biofilm.
Biomedicines 2022, 10, 956. (DOI: 10.3390/biomedicines10050956)


Kuratli J, Leonard CA, Frohns A, Schoborg R, Piazena H, Borel N.
Refinement of water-filtered infrared A (wIRA) irradiations of in vitro acute and persistent chlamydial infections. J Photochem Photobiol B. 2022 Sep;234:112533. (DOI: 10.1016/j.jphotobiol.2022.112533)


Klemm P, Aykara I, Eichelmann M, Neumann E, Frommer K, Lange U.
Treatment of back pain in active axial spondyloarthritis with serial locoregional water-filtered infrared A radiation: A randomized controlled trial.
J Back Musculoskelet Rehabil. 2022;35(2):271-278. (DOI: 10.3233/BMR-210068)


Chrubasik-Hausmann S, Hellwig E, Müller M, Al-Ahmad A.
Antimicrobial Photodynamic Treatment with Mother Juices and Their Single Compounds as Photosensitizers.
Nutrients 2021; 13: 710 (DOI: 10.3390/nu13030710).


Notter M, Thomsen AR, Grosu A-L, Vaupel P.
Recommendation of Regional Hyperthermia in the Treatment of Breast Cancer.
Integr Cancer Ther 2021; 20:1534735420988606 (DOI: 10.1177/1534735420988606).


Notter M, Stutz E, Thomsen AR, Vaupel P.
Radiation-Associated Angiosarcoma of the Breast and Chest Wall Treated with Thermography-Controlled, Contactless wIRA-Hyperthermia and Hypofractionated Re-Irradiation.
Cancers 2021;13(15):3911 (DOI: 10.3390/cancers13153911).


Peikert SA, Fischer A, Kruse AB, Al-Ahmad A, Woelber JP, Vach K, Braun A, Ratka-Krüger P.
Adjuvant Transgingival Therapy with Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) in Periodontal Therapy-A Randomized, Controlled, Stratified, Double-Blinded Clinical Trial.
Antibiotics 2021, 10, 251. (DOI:10.3390/antibiotics10030251).


Wiegand C, Hipler U-Ch, Elsner P, Tittelbach J.
Keratinocyte and Fibroblast Wound Healing In Vitro Is Repressed by Non-Optimal Conditions but the Reparative Potential Can Be Improved by Water-Filtered Infrared A.
Biomedicines 2021; 9: 1802 (DOI: 10.3390/biomedicines9121802).


Karygianni L, Ruf S, Hellwig E, Follo M, Vach K, Al-Ahmad A. Karygianni L, Ruf S, Hellwig E, Follo M, Vach K, Al-Ahmad A.
Antimicrobial Photoinactivation of In Situ Oral Biofilms by Visible Light Plus Water-Filtered Infrared A and Tetrahydroporphyrin-tetratosylate (THPTS). Microorganisms 2021; 9:145 (DOI: 10.3390/microorganisms9010145).


Frohns A, Stojanovic M, Barisani-Asenbauer T, Kuratli J, Borel N, Inic-Kanada A.

Effects of water-filtered infrared A and visible light (wIRA/VIS) radiation on heat- and stress-responsive proteins in the retina and cornea of guinea pigs. 
J Photochem Photobiol B. 2021; 224:112306.
(DOI: 10.1016/j.jphotobiol.2021.112306)


Nitsche M, Dunst J, Krug D, Meyer R, Herman RM:
Strahlentherapie mit Hyperthermie beim Mammakarzinom.
Der Gynäkologe 2021/06/25. (DOI:10.1007/s00129-021-04816-2)


Schuester L, Liebl M E, Stroux A, Reißhauer A:

Wassergefiltertes Infrarot A (wIRA) bei Gonarthrose – eine prospektive randomisierte kontrollierte Studie. (Water-Filtered Infrared A (wIRA) Treatment of Knee Osteoarthritis – A Prospective Randomized Controlled Study.)
Phys Med Rehab Kuror 2021; 22 Feb online. (DOI: 10.1055/a-1349-1482)


Klemm P, Eichelmann M, Aykara I, Hudowenz O, Dischereit G, Lange U:
Serial locally applied water-filtered infrared a radiation in axial spondyloarthritis – a randomized controlled trial.
Int J Hyperthermia 2020; 37/1:965-970. (DOI: 10.1080/02656736.2020.1804079)


Notter M, Thomsen AR, Nitsche M, Hermann RM, Hendrik A, Wolff HA, Habl G, Münch K, Grosu AL, Vaupel P:
Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification.
Cancers 2020; 12(3), 606. (DOI:10.3390/cancers12030606)


Thomsen AR, Vaupel P, Grosu A-L, Notter M:
Correspondence: Hyperthermia Plus Re-Irradiation in the Management of Unre-sectable Locoregional Recurrence of Breast Cancer in Previously Irradiated Sites.
J Clin Oncol 2020; 38:3576-3577 (DOI: 10.1200/JCO.20.01857)


Piazena H, Müller W, Vaupel P:
wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia. 
Int J Hyperthermia 2020; 37/1:887-896. (DOI: 10.1080/02656736.2020.1792562)


Inic-Kanada A, Stojanovic M, Miljkovic R, Stein E, Filipovi A, Frohns A, Zöller N, Kuratli J, Barisani-Asenbauer T, Borel N:
Water-filtered Infrared A and visible light (wIRA/VIS) treatment reduces Chlamydia caviae-induced ocular inflammation and infectious load in a Guinea pig model of inclusion conjunctivitis.
J Photochem Photobiol B. 2020; 209:111953 
(DOI: 10.1016/j.jphotobiol.2020.111953)


Kok HP, Cressman ENK, Ceelen W, Brace CL, Ivkov R, Grüll H, ter Haar G, Wust P, Crezee J:
Heating technology for malignant tumors: a review.

Int J Hyperthermia 2020; 37/1:711-741. (DOI:10.1080/02656736.2020.1779357)


Rühle A, Thomsen A, Saffrich R, Voglstätter M, Bieber B, Sprave T, Wuchter P, Vaupel P, Huber PE, Grosu A-L and Nicolay NH:
Multipotent mesenchymal stromal cells are sensitive to thermic stress –potential implications for therapeutic hyperthermia.
Int J Hyperthermia 2020; 37/1:430-441. (DOI: 10.1080/02656736.2020.1758350)


Borel N, Sauer-Durand AM, Hartel M, Kuratli J, Vaupel P, Scherr N, Pluschke G:
wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria.
Int J Hyperthermia 2020; 37(1):373-383. (DOI: 10.1080/02656736.2020.1751312)


Scheel-Sailer A, Aliyev N, Jud D, Annaheim S, Harder Y, Krebs J, Wildisen A, Wettstein R:
Changes in skin-physiology after local heat application using two different methods in individuals with complete paraplegia: a feasibility and safety trial. Spinal Cord 2020; 58, 667-674. (DOI: 10.1038/s41393-019-0408-8


Xu J, Deng Y, Yu CY, et al:
Efficacy of wIRA in the treatment of sacroiliitis in male patients with ankylosing spondylitis and its effect on serum VEGF levels.
J Orthop Surg Res. 2019; 14(1):313. (DOI: 10.1186/s13018-019-1322-7)


Vollmer A, Al-Ahmad A, Argyropoulou A, Thurnheer T, Hellwig E, Attin T, Vach K, Wittmer A, Ferguson K, Skaltsounis AL, Karygianni L:
Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS+wIRA) and Hypericum Perforatum Modifies In Situ Oral Biofilms.
Sci Rep 2019; 9/20325. (DOI:10.1038/s41598-019-56925-7)


Piazena H, Müller W, Pendl W, von Ah S, Cap VH, Hug PJ, Sidler X, Pluschke G, Vaupel P:
Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens.
Int J Hyperthermia 2019; 36/1:937-951. (DOI: 10.1080/02656736.2019.1655594)


Stange R:

Nicht-onkologische Behandlungsmöglichkeiten mit wassergefiltertem Infrarot A (wIRA).

Tagungsbericht der Bundesagentur für Arbeitsschutz und Arbeitsmedizin „Licht und Gesundheit“, 1. Auflage 2019; 91-95. (DOI: 10.21934/baua:bericht20190201)


Kuratli J, Borel N:
Perspective: Water-Filtered Infrared-A-Radiation (wIRA) – Novel Treatment Options for Chlamydial Infections?
Front Microbiol 2019; 10:1053. (DOI: 10.3389/fmicb.2019.01053)


Sachse C, Guendling PW, Michalsen A, Steckhahn N, Uehleke B, Stange R:
Randomized controlled pilot study on the effectiveness and tolerance of mild whole body hyperthermia for patients with irritable bowel syndrome.
Anticancer Research 2019; 39:3292-93. Poster No. 6. Biological Effects of Light, Homburg, Saarland, Germany, June 5-7, 2019


Burchard T, Karygianni L, Hellwig E, Follo M, Wrbas T, Wittmer A, Vach K,

Al-Ahmad A:
Inactivation of oral biofilms using visible light and waterfiltered infrared A radiation and indocyanine green.
Future Med Chem 2019; 11/14. (DOI: 10.4155/fmc-2018-0522)


Kuratli J, Pesch Th, Marti H, Leonard CA, Blenn Ch, Torgerson P, Borel N:
Water Filtered Infrared A and Visible Light (wIRA/VIS) Irradiation Reduces Chlamydia trachomatis Infectivity Independent of Targeted Cytokine Inhibition. Front Microbiol 2018; November 15. (DOI: 10.3389/fmicb.2018.02757)


Aljasir A, Pierson T, Hoffmann G, Menke H:
Management of donor site infections in split-thickness skin graft with water-filtered infrared-A (wIRA). 
GMS Interdiscip Plast Reconstr Surg DGPW 2018; 7:Doc03.
(DOI: 10.3205/iprs000123)
König A, Missalla S, Valesky EM, Bernd A, Kaufmann R, Kippenberger S, et al:
Effect of NIR photobiomodulation therapy in a cellular wound healing model. Photodermatol Photoimmunol Photomed 2018. (DOI: 10.1111/phpp.12390)
Vaupel P, Piazena H, Müller W, Notter M:
Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumours.
Int J Hyperthermia, 2018. (DOI: 10.1080/02656736.2018.1469169)
Hoffmann G:
Water-filtered infrared-A (wIRA) overcomes swallowing disorders and hypersalivation – a case report -bilingual- [Wassergefiltertes Infrarot A (wIRA) überwindet Schluckstörungen und vermehrte Speichelbildung – ein Fallbericht]. GMS Ger Med Sci. 2017; 15:Doc11. (DOI: 10.3205/000252)
Piazena H, Meffert H, Uebelhack R:
Spectral remittance and  transmittance of visible and of infrared-A radiation in human skin Comparison between in vivo measurements and model calculations.
Photochem. Photobiol, 2017; 93: 1449–1461. (DOI: 10.1111/php.12775)
Notter M, Piazena H, Vaupel P:
Hypofractionated re-irradiation of large-sized recurrent breast cancer with thermography-controlled, contact-free water-filtered infrared-A hyperthermia: a retrospective study of 73 patients.
Int J Hyperthermia 2017; 33/2:227-236. (DOI:10.1080/02656736.2016.1235731)
Piazena H:
Sonnencremes mit Infrarot-A-Schutz?
DERM 2016; 22:532-538, OmniMed Verlagsgesellschaft mbH, Hamburg


Ali Al-Ahmad A, Walankiewicz A, Hellwig E, Follo M, Tennert C, WittmerA, Karygianni L:
Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (visCwIRA) and Chlorine e6 (Ce6) Eradicates Planktonic Periodontal Pathogens and Subgingival Biofilms.
Front Microbiol 2016; 7:1900. (DOI: 10.3389/fmicb.2016.01900)

Rahn C, Marti H, Frohns A, Frohns F, Blenn Ch, Leonard CA, Barisani-Asenbauer T, Stein E, Borel N:
Water-filtered infrared A reduces chlamydial infectivity in vitro without causing ex vivo eye damage in pig and mouse models.
J Photochem Photobiol B. 2016, 165:340-350.
(DOI: 10.1016/j.jphotobiol.2016.11.001)

Zöller N, König A, Butting M, Kaufmann R, Bernd A, Valesky E, Kippenberger S:
Water-filtered near-infrared influences collagen synthesis of keloid-fibroblasts in contrast to normal foreskin fibroblasts.
J Photochem Photobiol 2016, 163:194-202. (DOI: 10.1016/j.jphotobiol.2016.08.020)

Hoffmann G, Hartel M, Mercer JB:
Heat for wounds – water-filtered infrared-A (wIRA) for wound healing – a review. GMS Ger Med Sci. 2016; 14:Doc08. (DOI: 10.3205/000235)

Janssen CW, Lowry CA, Mehl MR, Allen JJ, Kelly KL, Gartner DE, Medrano A, et al.:
Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial.
JAMA Psychiatry 2016; 73/8: 789-795. (DOI: 10.1001/jamapsychiatry.2016.1031)

Rich LJ, Winslow TB, Alberico RA, Repasky EA, Seshadri M, Singh AK:
Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer.
Int J Hyperthermia 2016; 32/5: 539-542. (DOI: 10.3109/02656736.2016.1167259)


Knels L, Valtink M, Piazena H, Marin JV, Gommel K, Lupp A, Roehlecke C, Mehner M, Funk RH:
Effects of Narrow-band IR-A and of Water-filtered Infrared A (wIRA) on Fibroblasts.
Photochem Photobiol. 2016; 92:475-487. (DOI: 10.1111/php.12579)


Müller W:
The Sun’s infrared-A protects the skin.
Press Release of AWMF, 02-02-2016.


Diffey B, Cadars B:
An appraisal of the need for infrared radiation protection in sunscreens. Photochem. Photobiol. Sci., 2016; 15:361-364. (DOI: 10.1039/c5pp00451a)


Barolet D, Christiaens F, Hamblin MR:
Infrared and skin: Friend or foe.
J Photochem Photobiol B. 2016; 155:78-85. (DOI: 10.1016/j.jphotobiol.2015.12.014)


Däschlein G, Napp M, Söhnel A, von Podewils S, Lutze S, Arnold A, Jünger M:
Photodynamic therapy in dermatology: Actual indications and new alternative therapies.
Congress report from the First Sino-German Symposium.
Photon Lasers Med 2015; 4(4):381–385. (DOI 10.1515/plm-2015-0032)


Marti H, Blenn Ch, Borel N:
The contribution of temperature, exposure intensity and visible light to the inhibitory effect of irradiation on acute chlamydial infection.
Photochem Photobiol 2015; 153:324-333. (DOI:10.1016/j.jphotobiol.2015.10.012)


Al-Ahmad A, Bucher M, Anderson AC, Tennert C, Hellwig E, Wittmer A, Vach K, Karygianni L:
Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) Alters In Situ Oral Biofilms.
PLoS ONE 2015; 10(7): e0132107. (DOI:10.1371/journal.pone.0132107)


Höhn A, Hartmann P, Grune V, Sonntag J, Grune T, Jung T:
Actual Isothermal Effect of Water-Filtered Infrared A (wIRA)-Irradation. Photochem Photobiol 2015; 91(4):887-94. (DOI: 10.1111/php.12439)


Dombrovsky LA, Timchenko V, Pathak C, Piazena H, Müller W, Jackson M:
Radiative heating of superficial human tissues with the use of water-filtered infrared-A radiation: A computational modeling.
Int. J. Heat Mass Transfer 2015; 85:311-320. (DOI:10.1016/j.ijheatmasstransfer.2015.01.133)


Karygianni L, Ruf S, Follo M, Hellwig E, Bucher M, Anderson A, Vach K, Al-Ahmad A:
Novel Broad-Spectrum Antimicrobial Photoinactivation of In Situ Oral Biofilms Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA).
Appl Environ Microbiol 2014; 80(23):7324–7336. (DOI: 10.1128/AEM.02490-14)


Marti H, Koschwanez M, Pesch T, Blenn Ch, Borel N:
Water-Filtered Infrared A Irradiationin Combination with Visible Light Inhibits Acute Chlamydial Infection.
PLOS ONE2014; 9(7): e102239. (DOI: 10.1371/journal.pone.0102239)


Piazena H, Meffert H, Uebelhack R:
Physikalische und photobiologische Grundlagenprophylaktischer und therapeutischer Infrarotanwendungen.
Akt Dermatol 2014; 40: 1–5. (DOI: 10.1055/s-0034-1365750)


Piazena H, Meffert H, Uebelhack R:
Wassergefiltertes Infrarot-A (wIRA) – ein effektives Mittel für die intensive Thermotherapie – physikalische und photobiologische Grundlagen.
In: Völker S. Hrsg. Achtes Symposium „Licht und Gesundheit". EineSondertagung der TU-Berlin gemeinsam mit DAfP und LiTG, Berlin, 19./20.03.2014.S. 73-79. ISBN: 978-3-7983-2671-2 (print); ISBN: 978-3-7983-2671-9 (online)


Piazena H, Pittermann W, Müller W, Jung K, Kelleher DK, Herrling T, Meffert P, Uebelhack R, Kietzmann M:
Effects of water-filtered infrared-A and of heat on cell death, inflammation, antioxidative potential and of free radical formation in viableskin – First Results. J Photochem Photobiol 2014; 138: 347-354. (DOI:10.1016/j.jphotobiol.2014.06.007)


 Hoffmann G:
Wassergefiltertes Infrarot-A (wIRA) in der Sport- und Präventivmedizin.
Völker S. Hrsg. Achtes Symposium „Licht und Gesundheit." Eine Sondertagung der TU-Berlin gemeinsam mit DAfP und LiTG,Berlin, 19./20.03.2014. S. 80-105.
ISBN: 978-3-7983-2671-2 (print); ISBN:978-3-7983-2671-9 (online)


Hainfeld JF, O'Connor MJ, Lin P, Qian L, Slatkin DN, Smilowitz HM:
Infrared-Transparent Gold Nanoparticles Converted by Tumors to Infrared Absorbers Cure Tumors in Mice by Photothermal Therapy.
PLoS ONE 2014; 9(2): e88414. (DOI:10.1371/journal.pone.0088414)


Hainfeld JF, Lin L, Slatkin DN, Dilmanian FA, Vadas TM, Smilowitz HM:
Gold nanoparticlehyperthermia reduces radiotherapy dose.
Nanomedicine 2014; 10(8): 1609–1617. (DOI:10.1016/j.nano.2014.05.006)


Marti H, Koschwanez M, Pesch T, Blenn Ch, Borel N:
Water-Filtered Infrared A Irradiationin Combination with Visible Light Inhibits Acute Chlamydial Infection.
PLOS ONE2014; 9(7): e102239. (DOI: 10.1371/journal.pone.0102239)


Kuenzli BM, Liebl F, Nuhn PH, Schuster T, Friess H, Hartel M:
Impact of Preoperative Local Water-Filtered Infrared-A (wIRA) Irradiation on Postoperative Wound Healing - A Randomized Patient- and Observer Blinded Controlled Clinical Trial.
2013, Annals of Surgery. 258(6):887-94. (DOI: 10.1097/SLA.0000000000000235)
Al-Ahmad A, Tennert C, Karygianni L, Wrbas KT, Hellwig E, Altenburger M:
Antimicrobial Photodynamic therapy using visible light plus water-filtered infrared-A (wIRA).

J Med Microbiol 2013; 62,(Pt 3):467-73. (DOI 10.1099/jmm.0.048843-0)
Kelleher D, Piazena H:
The interpretation of clinical studies on the photodynamic treatment of actinic keratosis.
Letter to the Editor. GMS Ger Med Sci 2012;10:Doc17. (DOI: 10.3205/000168)
Jung T, Grune T:
Experimental basis for discriminating between thermal and athermal effects of water-filtered infrared A irradiation.
Ann. N.Y. Acad. Sci. 2012; 1259: 33–38. (DOI: 10.1111/j.1749-6632.2012.06581.x)
Knels L, Valtink M, De la Vega Marin J, Steiner G, Roehlecke C, Krueger A. Funk RWH:
Effects of temperature and water-filtered infrared-A alone or in combination on healthy and Glyoxal-stressed fibroblast cultures.
Oxidative Medicine and Cellular Longevity 2012, Article ID 274953, 8 pages. (DOI:10.1155/2012/274953)
Heselich A, Frohns F, Frohns A, Naumann SC:
Layer PG: Near-infrared exposure changes cellular responses to ionizing radiation. Photochemistry and photobiology 2012; 88(1): 135-46. ISSN 1751-1097.
(DOI: 10.1111/j.1751-1097.2011.01031.x)
Sulyok I, Fleischmann E, Stift A, Roth G, Lebherz-Eichinger D, Kasper D, Spittler A, Kimberger O:
Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery.
Br J Anaesth. 2012 Nov;109(5):754-61. (DOI: 10.1093/bja/aes248.)


Hoffmann G:
Wassergefiltertes Infrarot A in Chirurgie, Dermatologie, Sportmedizin und weiteren Bereichen.
In: Krause R, Stange R (Hrsg): Lichttherapie. Berlin, Heidelberg, New York: Springer, 2012, S. 25-54. ISBN 13: 978-3-642-16938-0.
Auch online verfügbar: URN: urn:nbn:de:hebis:30:3-241715 ;


Jung T, Höhn A, Lau A-M, Piazena H, Grune T:
An experimental setup for the measurement of non-thermal effects during water-filtered infrared A (wIRA)-irradiation of mammalian cell cultures.
Photochem Photobiol 2012: 88 (2): 371-380.(DOI: 10.1111/j.1751-1097.2011.01072.x)


Daeschlein G, Alborovac J, Patzelt A, Kramer A, Lademann J:
Kinetics of Physiological Skin Flora in a Suction Blister Wound Model on Healthy Subjects after Treatment with Water-Filtered Infrared-A Radiation.
Skin Pharmacol Physiol 2012;25 (2): 73-77. (DOI: 10.1159/000332753)


von Felbert V, Kernland-Lang K, Hoffmann G, Wienert V, Simon D, Hunziker T:
Irradiation with water-filtered infrared-A (wIRA) plus visible light improves cutaneous scleroderma lesions in a series of cases.
Dermatology 2011: 222: 347–357. (DOI: 10.1159/000329024)


Schumann H, Calow T, Weckesser S, Müller ML, Hoffmann G:
Water-filtered infrared-A (wIRA) for the treatment of chronic venous stasis ulcers of the lower legs at home – a randomized controlled blinded study.
Br J Dermatol 2011: 165: 541–551. (DOI 10.1111/j.1365-2133.2011.10410.x)


von Felbert V, Kernland-Lang K, Hoffmann G, Wienert V, Simon D, Hunziker T:
Irradiation with water-filtered infrared-A (wIRA) plus visible light improves cutaneous scleroderma lesions in a series of cases.
Dermatology 2011. (accepted for publication)


Schumann H, Calow T, Weckesser S, Müller ML, Hoffmann G:
Water-filtered infrared-A (wIRA) for the treatment of chronic venous stasis ulcers of the lower legs at home - a randomized controlled blinded study.
Br J Dermatol 2011 (


Notter M, Germond JF, Wolf E, Berz R, Berz J:
Thermography guided irradiation using water-filtered Infrared-A (wIRA) and radiotherapy on recurrent breast cancer - first experiences and temperature analysis.
Thermology International 2011: 21 (2): 47-53


Müller W:
Infrarot A der Sonne schädigt die Haut nicht. The Sun’s infrared-A is not detrimental to the skin.
Pressemitteilung der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften AWMF im Informationsdienst Wissenschaft idw, veröffentlicht am 15.07.2010. (deutsch) und (English)


von Felbert V, Hoffmann G, Hoff-Lesch S, Abuzahra F, Renn CN, Neugebauer S, Braathen LR, Merk HF:
Photodynamic therapy of multiple actinic keratoses: Reduced pain through use of visible light plus water-filtered infrared-A (wIRA) compared to light from light-emitting diodes.
Brit J Dermatol 2010: 163/3:607-615. (DOI: 10.1111/j.1365-2133.2010.09817.x)


Piazena H, Kelleher DK:
Effects of Infrared-A Irradiation on Skin: Discrepancies in Published Data Highlight the Need for an Exact Consideration of Physical and Photobiological Laws and Appropriate Experimental Settings.
Photochem Photobiol 86,687-705 (2010). (DOI: 10.1111⁄j.1751-1097.2010.00729.x)


Jung T, Höhn A, Piazena H, Grune T:
Effects of water-filtered infrared-A (wIRA) irradiation on human fibroblasts.
Free Radic Biol Med 2010; 48/1: 153-60. (DOI:10.1016/j.freeradbiomed.2009.10.036)


Geißler E und Schumann H:

Wassergefiltertes Infrarot A (wIRA) bei ulzerierter Morphea. Water-filtered infrared–A (wIRA) in ulcerated morphea.
Z Wundheil. 2009: 14(3): 177-80.


Hoffmann G:
Water-filtered infrared-A (wIRA) in acute and chronic wounds [review article]. Wassergefiltertes Infrarot A (wIRA) bei akuten und chronischen Wunden.
GMS Krankenhaushyg Interdiszip. 2009;4(2):Doc12.
(DOI: 10.3205/dgkh000137< URN: urn:nbn:de:0183-dgkh0001373)


Mercer JB, Nielsen SP, Hoffmann G:
Improvement of wound healing by water-filtered infrared-A (wIRA) in patients with cronic venous statis ulcers of the lower legs including evaluation using infrared thermography.
GMS Ger Med Sci. 2008;6:Doc1
Research Article


Krüger S, Lipski A, Jahr S, Kujath K, Mathiske-Schmidt K, Reißhauer A:
Serielle wassergefilterte Infrarot A Bestrahlung mit Fahrradergometrie (Hydrosun®) bei Fibromyalgiepatienten.
Phys Med Rehab Kuror 2008; 18: 216 (12)


Wilsmann-Theis D, Bieber T, Novak N:
Photodynamic Therapy as an Alternative Treatment for Cutaneous Sarcoidosis. Dermatology 2008; 217: 343-346.


Löwe V, Singer D:
Quantitative Thermographie bei Neugeborenen unter verschiedenen Arten von Wärmestrahlung.
Z Geburtsh Neonatol 2008; 212: S92, P148, ISSN 1615-5300


Otberg N, Grone D, Meyer L, Schanzer S, Hoffmann G, Ackermann H, Sterry W, Lademann J:
Water-filtered infrared-A (wIRA) can act as a penetration enhancer for topically applied substances. Wassergefiltertes Infrarot A (wIRA) kann als Penetrations-verstärker für topisch aufgetragene Substanzen wirken.
GMS Ger Med Sci. 2008; 6:Doc08.
Research Article


Hoffmann G:
Überblicksarbeit zu wassergefiltertem Infrarot-A (wIRA): Klinische Anwendungen von wassergefiltertem Infrarot A (wIRA).
In: Kaase H., Serick, F., Hrsg.: Sechstes Symposium "Licht und Gesundheit".
Eine Sondertagung der Technischen Universität Berlin und der Deutschen Gesellschaft für Photobiologie mit der Deutschen Akadmie für Photobiologie und Phototechnologie und der Deutschen Lichttechnischen Gesellschaft, Berlin, 13./14.03.2008. Berlin; 2008. S. 130-146. ISBN: 3-9807635-0-3.


Hoffmann G:
Wassergefiltertes Infrarot A (wIRA) zur Verbesserung der Wundheilung bei aktuen und chronischen Wunden. Water filtered Infrared A (wIRA) for the improvement of wound healing in acute and chronic wounds.
Wundmanagement 2008; 2: 72-80


von Felbert V, Schumann H, Mercer JB, Strasser W, Daeschlein G, Hoffmann G: Therapy of chronic wounds with water-filtered infrared-A (wIRA). Therapie chronischer Wunden mit wassergefiltertem Infrarot A (wIRA).
GMS Krankenhaushyg Interdiszip. 2007;2(2):Doc52.
Review Article


Hartel M, Illing P, Mercer JB, Lademann J, Daeschlein G, Hoffmann G:
Therapy of acute wounds with water-filtered infrared-A (wIRA)
Therapie akuter Wunden mit wassergefiltertem Infrarot A (wIRA).
Review Article. GMS Krankenhaushyg Interdiszip. 2007; 2 (2):Doc53.
Review Article


Hoffmann G:
Principles and working mechanisms of water-filtered infrared-A (wIRA) in relation to wound healing.
Grundlagen und Wirkprinzipien von wassergefiltertem Infrarot A (wIRA) in Bezug zur Wundheilung. Review Article.
GMS Krankenhaushyg Interdiszip 2007;2(2):Doc54.
Review Article


Gebbers N, Hirt-Burri N, Scaletta C, Hoffmann G, Applegate LA:
Water-filtered infrared-A radiation (wIRA) is not implicated in cellular degeneration of human skin. Wassergefilterte Infrarot-A-Strahlung (wIRA) ist nicht an der Zelldegeneration menschlicher Haut beteiligt.
GMS Ger Med Sci. 2007;5:Doc08.
Research Article


Voss P, Hajimiragha H, Engels M, Ruhwiedel C, Calles C, Schroeder P, Grune T: Irradiation of GAPDH: a model for environmentally induced protein damage.
Biol Chem. 2007; 388(6): 583-92.


Hartel M, Hoffmann G, Wente MN, Martignoni ME, Büchler MW, Friess H: Randomized clinical trial of the influence of local water-filtered infrared A irradiation on wound healing after abdominal surgery.
Br J Surg. 93(8):952-60. DOI: 10.1002/bjs.5429; 2006.


Möckel F, Hoffmann G, Obermüller R, Drobnik W, Schmitz G:
Influence of water-filtered infrared-A (wIRA) on reduction of local fat and body weight by physical exercise.
GMS Ger Med Sci. 2006;4:Doc05
Research Article


Frank S, Menezes S, Lebreton-De Coster C, Oster M, Dubertret L, Coulomb B: Infrared radiation induces the p53 signaling pathway: role in infrared prevention of ultraviolet B toxicity.
ExpDermatol. 2006;15(2):130-7.


Hoffmann G:
Water-filtered infrared A (wIRA) for the improvement of wound healing. Wassergefiltertes Infrarot A (wIRA) zur Verbesserung der Wundheilung.
GMS Krankenhaushyg Interdiszip. 2006;1(1)


Mercer, J B, de Weerd L:
The effect of water-filtered infrared-A (wIRA) irradiation on skin temperature and skin blood flow as evaluated by infrared thermography and scanning laser Doppler imaging.
Thermology international 2005; 15: 89-94.


Fuchs M, Fluhr JW, Bankova L, Tittelbach J, Hoffmann G, Elsner P:
Photodynamic therapy (PDT) and waterfiltered infrared A (wIRA) in patients with recalcitrant common hand and foot warts.
German Medical Science Vol. 2, Doc08, 2004.
Research Article


Burri N, Gebbers N, Applegate L.A:
Chronic infrared-A radiation repair: Implications in cellular senescence and extracellular matrix.
In: Pandalai SG, ed. Recent Research Developments in Photochemistry & Photobiology, Vol. 7. Trivandrum: Transworld Research Network; 2004. p. 219-31
Online reference


Bräuer A, Weyland W, Kazmaier S, Trostdorf U, Textor Z, Hellige G, Braun U: Efficacy of Postoperative Rewarming after Cardiac Surgery.
In: Ann. Thorc. Cardiovasc Surg. Vol. 10 No. 3, 171-177, 2004.


Kelleher DK, Bastian J, Thews O, Vaupel P:
Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours.
British Journal of Cancer 89: 405-411, 2003.


Danno K, Mori N, Toda K, Kobayashi T, Utani A:
Near-infrared irradiation stimulates cutaneous wound repair: laboratory experiments on possible mechanisms.
Photodermatol Photoimmunol Photomed. 2001;17(6):261-5.


Applegate LA, Scaletta C, Panizzon R, Frenk E, Hohlfeld P, Schwarzkopf S: Induction of the putative protective protein ferritin by infrared radiation: Implications in skin repair.
International Journal of Molecular Medicine 5: 247-251, 2000


Singer D, Schröder M, Harms K:
Vorteile der wassergefilterten gegenüber herkömmlicher Infrarot-Strahlung in der Neonatologie.
In: Z. Geburtsh. Neonatol 204: 85-92, 2000, Thieme Verlag, Stuttgart, New York


Menezes S, Coulomb B, Lebreton C, Dubertret L:
Non-coherent near infrared radiation protects normal human dermal fibroblasts from solar ultraviolet toxicity.
J Invest Dermatol. 1998;111(4): 629-33.


Falkenbach A, Dorigoni H, Werny F, Gütl S:

Wassergefilterte Infrarot-A-Bestrahlungen bei Morbus Bechterew und degenerativen Wirbelsäulenver-änderungen: Effekte auf Beweglichkeit und Druckschmerzhaftigkeit. Water-filtered infrared A radiation in ankylosing spondylitis and in degenerative diseases of the spine: effects on mobility and pain on pressure.
Österr Z Phys Med, 1996;6: 96-102


Vaupel P, Rzeznik J, Stofft E:
Wassergefilterte Infrarot-A-Strahlung versus konventionelle Infrarotstrahlung: Temperaturprofile bei lokoregionaler Wärmetherapie.
In: Phys rehab Kur Med 5: 77-81, 1995. Abstract im Internet nicht vorhanden.


Hellige G, Becker G, Hahn G:
Temperaturverteilung und Eindringtiefe wassergefilterter Infrarot-A-Strahlung.
In: Vaupel, P. und Krüger, W. (Hrsg.) Wärmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsmöglichkeiten, 2 Auflage: 63-80, 1995, Hippokrates, Stuttgart.
Temperaturverteilung und Eindringtiefe.pdf


Cobarg CC:
Physikalische Grundlagen der wassergefilterterten Infrarot-A-Strahlung.
In: Vaupel, P. und Krüger, W. (Hrsg.) Wärmetherapie mit wassergefilterter Infrarot-A-Strahlung, Grundlagen und Anwendungsmöglichkeiten, 2 Auflage: 19-28, 1995, Hippokrates, Stuttgart.

Physikalische Grundlagen.pdf


Hoffmann G:
Basics of hyperbaric oxygenation and waterfiltered ultrared-A induced localized hyperthermia in Dermatology.
Oxygen Transport to Tissue XV: 181-188, 1994, Plenum Press, New York


Buchmüller K:
Über die ultrarote Emmissionsreflexion und Durchlässigkeit der lebenden menschlichen Haut im Spektralbereich.
In: Pflügers Arch. Ges. Physiol.: 272-360, 1961